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Target
Fatty-acid amide hydrolase 1 [33-574]
Ligand
BDBM50437232
Substrate
n/a
IC50
137±31 nM
Citation
 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Development of fragment-based n-FABS NMR screening applied to the membrane enzyme FAAH. Chembiochem 14:1611-9 (2013) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1 [33-574]
Synonyms:
FAAH1_RAT | Faah | Faah1 | Fatty-acid amide hydrolase (rFAAH∆TM)
Type:
Protein
Mol. Mass.:
59459.86
Organism:
Rattus norvegicus (Rat)
Description:
97-1722bp
Residue:
542
Sequence:
GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP
  
Inhibitor
Name:
BDBM50437232
Synonyms:
3‐(3‐carbamoylphenyl)‐4‐methoxyphenyl N‐ cyclohexylcarbamate (Compound 3) | CHEMBL2402921 | US9187413, 1c
Type:
Small organic molecule
Emp. Form.:
C21H24N2O4
Mol. Mass.:
368.4263
SMILES:
COc1ccc(OC(=O)NC2CCCCC2)cc1-c1cccc(c1)C(N)=O
Structure:
Search PDB for entries with ligand similarity: