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Target
Cell surface glycoprotein MUC18
Ligand
BDBM111085
Substrate
n/a
Meas. Tech.
Mushroom Tyrosinase Assay
Temperature
298.15±n/a K
IC50
50000±n/a nM
Comments
extracted
Citation
 Nandy, SK; Liu, J; Nesterov, AM; Hertel, C; Papmapiya, AA Series of skin-whitening (lightening) compounds US Patent  US9682910 Publication Date 6/20/2017 
Target
Name:
Cell surface glycoprotein MUC18
Synonyms:
Gicerin | MUC18_MOUSE | Mcam | Melanoma cell adhesion molecule | Melanoma-associated antigen MUC18 | Muc18
Type:
Protein
Mol. Mass.:
71536.56
Organism:
Mouse
Description:
Q8R2Y2
Residue:
648
Sequence:
MGLPKLVCVFLFAACCCCRRAAGVPGEEKQPVPTPDLVEAEVGSTALLKCGPSRASGNFSQVDWFLIHKERQILIFRVHQGKGQREPGEYEHRLSLQDSVATLALSHVTPHDERMFLCKSKRPRLQDHYVELQVFKAPEEPTIQANVVGIHVDRQELREVATCVGRNGYPIPQVLWYKNSLPLQEEENRVHIQSSQIVESSGLYTLKSVLSARLVKEDKDAQFYCELSYRLPSGNHMKESKEVTVPVFYPAEKVWVEVEPVGLLKEGDHVTIRCLTDGNPQPHFTINKKDPSTGEMEEESTDENGLLSLEPAEKHHSGLYQCQSLDLETTITLSSDPLELLVNYVSDVQVNPTAPEVQEGESLTLTCEAESNQDLEFEWLRDKTGQLLGKGPVLQLNNVRREAGGRYLCMASVPRVPGLNRTQLVSVGIFGSPWMALKERKVWVQENAVLNLSCEASGHPQPTISWNVNGSATEWNPDPQTVVSTLNVLVTPELLETGAECTASNSLGSNTTTIVLKLVTLTTLIPDSSQTTGLSTLTVSPHTRANSTSTEKKLPQPESKGVVIVAVIVCTLVLAVLGAALYFFYKKGKLPCGRSGKQEITLPPTRKSEFVVEVKSDKLPEEMALLQGSNGDKRAPGDQGEKYIDLRH
  
Inhibitor
Name:
BDBM111085
Synonyms:
US9682910, 4-((2-Methoxypyridin-3-yl)methyl)benzene-1,3-diol (8)
Type:
Small organic molecule
Emp. Form.:
C13H13NO3
Mol. Mass.:
231.2472
SMILES:
COc1ncccc1Cc1ccc(O)cc1O
Structure:
Search PDB for entries with ligand similarity: