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Target
Histamine H3 receptor
Ligand
BDBM108278
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
1.4±0.0 nM
Citation
 Gao, Z; Hall, D; Hartung, R Substituted piperidine spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof US Patent  US8604046 Publication Date 12/10/2013 
Target
Name:
Histamine H3 receptor
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
43426.88
Organism:
Macaca mulatta (Rhesus macaque)
Description:
G7N499
Residue:
390
Sequence:
MLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAGGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGTAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEQCWK
  
Inhibitor
Name:
BDBM108278
Synonyms:
US8604046, 58
Type:
Small organic molecule
Emp. Form.:
C32H39F3N4O3
Mol. Mass.:
584.6723
SMILES:
C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCN(CC3)C(=O)c3ccc(OC(F)(F)F)cc3)C2=O)c(C)c1 |r|
Structure:
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