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TargetHistamine H3 receptor
LigandBDBM108295
Substrate/Competitorn/a
Meas. Tech.Radioligand Binding Assay
Ki 0.06±0.0 nM
Citation Gao, ZHall, DHartung, R Substituted piperidine spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof US Patent US8604046 Publication Date 12/10/2013
More Info.:Get all data from this article,  Assay Method
 
Histamine H3 receptor
Name:Histamine H3 receptor
Synonyms:n/a
Type:Enzyme
Mol. Mass.:43426.88
Organism:Macaca mulatta (Rhesus macaque)
Description:G7N499
Residue:390
Sequence:
MLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDY
LLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWE
YLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDG
AREAGGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGG
GGGTAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRK
VAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLC
HHSFRRAFTKLLCPQKLKIQPHSSLEQCWK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM108295
NameBDBM108295
Synonyms:US8604046, 75
TypeSmall organic molecule
Emp. Form.C31H41FN4O
Mol. Mass.504.6818
SMILESC[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCCC3(CCN(Cc4ccccc4)CC3)C2=O)c(F)c1 |r|
Structure
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n/a