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Target
Histamine H3 receptor
Ligand
BDBM108297
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
0.008±0.0 nM
Citation
 Gao, Z; Hall, D; Hartung, R Substituted piperidine spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof US Patent  US8604046 Publication Date 12/10/2013 
Target
Name:
Histamine H3 receptor
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
43426.88
Organism:
Macaca mulatta (Rhesus macaque)
Description:
G7N499
Residue:
390
Sequence:
MLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAGGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGTAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEQCWK
  
Inhibitor
Name:
BDBM108297
Synonyms:
US8604046, 77
Type:
Small organic molecule
Emp. Form.:
C29H44N4O3
Mol. Mass.:
496.6847
SMILES:
C[C@H]1CCCN1C1CCN(CC1)c1ccc(cc1)N1CCC2(CCN(CC2)C(=O)OC(C)(C)C)C1=O |r|
Structure:
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