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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM108377
Substrate
n/a
Meas. Tech.
Luminometric Kinase Assay
pH
7±0
IC50
71.3±0.0 nM
Citation
 Brzózka, K; Czardybon, W; Sabiniarz, A; Millik, M; Windak, R; Zarebski, A; Beuzen, N Compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent US Patent  US8604217 Publication Date 12/10/2013 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM108377
Synonyms:
US8604217, 128
Type:
Small organic molecule
Emp. Form.:
C14H10Br4N4
Mol. Mass.:
553.872
SMILES:
Brc1c(Br)c(Br)c2[nH]c(NCCc3ccccn3)nc2c1Br
Structure:
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