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Target
RAC-alpha serine/threonine-protein kinase
Ligand
BDBM108441
Substrate
n/a
Meas. Tech.
Alpha Screen Assay
pH
8±0
Temperature
298.15±0 K
IC50
3.77±n/a nM
Citation
 Ashwell, MA; Brassard, C; Filikov, A; Hill, J; Koerner, S; Lapierre, J; Liu, Y; Namdev, N; Nicewonger, R; Palma, R; Tandon, M; Vensel, D; Matsuda, A; Iimura, S; Yoshida, K; Yamazaki, T; Kitamura, T; Isoyama, T Substituted imidazopyridinyl-aminopyridine compounds US Patent  US8609688 Publication Date 12/17/2013 
Target
Name:
RAC-alpha serine/threonine-protein kinase
Synonyms:
AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT)
Type:
Enzyme
Mol. Mass.:
55681.25
Organism:
Homo sapiens (Human)
Description:
P31749
Residue:
480
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
  
Inhibitor
Name:
BDBM108441
Synonyms:
US8609688, 19
Type:
Small organic molecule
Emp. Form.:
C27H25N7
Mol. Mass.:
447.5343
SMILES:
Nc1ncccc1-c1nc2ccc(Nc3ccccc3)nc2n1-c1ccc(cc1)C1(N)CCC1
Structure:
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