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TargetAurora A/TPX2 (1-43)
LigandBDBM109206
Substrate/Competitorn/a
Meas. Tech.Dissociation Kinetics Assay
Kd 0.527±0.051 nM
Citation Lavogina, DEnkvist, EViht, KUri, A Long residence times revealed by Aurora A kinase-targeting fluorescent probes derived from inhibitors MLN8237 and VX-689. Chembiochem15:443-50 (2014) [PubMed]  Article
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Aurora A/TPX2 (1-43)
Name:Aurora A/TPX2 (1-43)
Synonyms:n/a
Type:n/a
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Aurora kinase A/Targeting protein for Xklp2
Synonyms:ARK1 | AURKA | Aurora kinase A | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:Serine/threonine-protein kinase
Mol. Mass.:45830.98
Organism:Homo sapiens (human)
Description:n/a
Residue:403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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Component 2
Name:TPX2 (1-43)
Synonyms:Microtubule-associated
Type:Protein
Mol. Mass.:5046.21
Organism:Homo sapiens (Human)
Description:n/a
Residue:44
Sequence:
MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENK
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BDBM109206
n/a
NameBDBM109206
Synonyms:2-[(1E,3E)-5-[(2E)-3-(3-{[(5R)-5-carbamoyl-5-[(4- {[13-chloro-10-(2-fluoro-6-methoxyphenyl)-3,5,9- triazatricyclo[9.4.0.0,⁷]pentadeca- 1(11),2(7),3,5,9,12,14-heptaen-4-yl]amino}-2- methoxyphenyl)formamido]pentyl]carbamoyl}propyl)-1- ethyl-3-methyl-5-sulfoindol-2-ylidene]penta-1,3- dien-1-yl]-1-ethyl-3,3-dimethylindol-1-ium-5- sulfonate (Compound I) | Compound I: MLN8237*-D-Lys(PromoFluor 647)-NH2
TypeSmall organic molecule
Emp. Form.C65H69ClFN9O11S2
Mol. Mass.1270.878
SMILESCCN1\C(=C\C=C\C=C\C2=[N+](CC)c3ccc(cc3C2(C)C)S([O-])(=O)=O)C(C)(CCCC(=O)NCCCC[C@@H](NC(=O)c2ccc(Nc3ncc4CN=C(c5cc(Cl)ccc5-c4n3)c3c(F)cccc3OC)cc2OC)C(N)=O)c2cc(ccc12)S(O)(=O)=O |r,c:9,54|
Structure
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