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Targetsodium-dependent glucose cotransporter 2 (SGLT2)
LigandBDBM109275
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50 3.65±0.0 nM
Citation Yang, FTang, PCDong, QTu, WFan, JGuan, DShen, GWang, YYuan, JZhang, L C-aryl glucoside derivatives, preparation process and pharmaceutical use thereof US Patent US8609622 Publication Date 12/17/2013
More Info.:Get all data from this article,  Assay Method
 
sodium-dependent glucose cotransporter 2 (SGLT2)
Name:sodium-dependent glucose cotransporter 2 (SGLT2)
Synonyms:Low affinity sodium-glucose cotransporter | Na(+)/glucose cotransporter 2 | Sodium/glucose cotransporter 2 | Solute carrier family 5 member 2
Type:Protein
Mol. Mass.:73014.31
Organism:Mus musculus (Mouse)
Description:Q923I7
Residue:670
Sequence:
MEQHVEAGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSM
VWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGV
ITMPQYLRKRFGGHRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALL
GITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAMTSLTV
SKDPSVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCL
AGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCS
NIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDKEL
LLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNE
KGAFWGLVGGLLMGLARLIPEFFFGSGSCVRPSACPALFCRVHYLYFAIILFICSGILTL
GISLCTAPIPQKHLHRLVFSLRHSKEEREDLDADELEGPAPAPVQNGGQECAMEMEEVQS
PAPGLLRRCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPRWARVVNLNALLMMT
VAVFLWGFYA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM109275
NameBDBM109275
Synonyms:US8609622, 2
TypeSmall organic molecule
Emp. Form.C21H21ClF2O7
Mol. Mass.458.837
SMILESCOc1ccc(Cc2cc(ccc2Cl)[C@@]23OC[C@@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)c(F)c1F |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a