Reaction Details Report a problem with these data
Target
Enteropeptidase
Ligand
BDBM109689
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
0.38±0.0 nM
Citation
 Konishi, A; Tokumasu, M; Suzuki, T; Koshiba, T; Ohsumi, K; Ikehara, O; Kodama, Y Heteroarylcarboxylic acid ester derivative US Patent  US8609715 Publication Date 12/17/2013 
Target
Name:
Enteropeptidase
Synonyms:
ENTK | ENTK_HUMAN | PRSS7 | TMPRSS15
Type:
Enzyme
Mol. Mass.:
112901.62
Organism:
Homo sapiens (Human)
Description:
P98073
Residue:
1019
Sequence:
MGSKRGISSRHHSLSSYEIMFAALFAILVVLCAGLIAVSCLTIKESQRGAALGQSHEARATFKITSGVTYNPNLQDKLSVDFKVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQFENGSIIVVFDLFFAQWVSDENVKEELIQGLEANKSSQLVTFHIDLNSVDILDKLTTTSHLATPGNVSIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQATHYPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTDILDIYEGVGSSKILRASIWETNPGTIRIFSNQVTATFLIESDESDYVGFNATYTAFNSSELNNYEKINCNFEDGFCFWVQDLNDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYISTPTGPGGRQERVGLLSLPLDPTLEPACLSFWYHMYGENVHKLSINISNDQNMEKTVFQKEGNYGDNWNYGQVTLNETVKFKVAFNAFKNKILSDIALDDISLTYGICNGSLYPEPTLVPTPPPELPTDCGGPFELWEPNTTFSSTNFPNSYPNLAFCVWILNAQKGKNIQLHFQEFDLENINDVVEIRDGEEADSLLLAVYTGPGPVKDVFSTTNRMTVLLITNDVLARGGFKANFTTGYHLGIPEPCKADHFQCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTACAENWTTQISNDVCQLLGLGSGNSSKPIFPTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFLH
  
Inhibitor
Name:
BDBM109689
Synonyms:
US8609715, B-46
Type:
Small organic molecule
Emp. Form.:
C16H17FN3O6PS
Mol. Mass.:
429.36
SMILES:
NC(=N)c1ccc(OC(=O)c2ccc(CCC(=O)NCP(O)(O)=O)s2)c(F)c1
Structure:
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