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Target
Tyrosine-protein kinase CSK
Ligand
BDBM110203
Substrate
n/a
Meas. Tech.
c-Src Kinase Inhibitory Activity Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
5.78e+4±n/a nM
Comments
extracted
Citation
 Chand, K; Prasad, S; Tiwari, RK; Shirazi, AN; Kumar, S; Parang, K; Sharma, SK Synthesis and evaluation of c-Src kinase inhibitory activity of pyridin-2(1H)-one derivatives. Bioorg Chem 53:75-82 (2014) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase CSK
Synonyms:
C-SRC kinase | C-src tyrosine kinase | CSK | CSK_HUMAN | Protein-tyrosine kinase CYL | Tyrosine Kinase CSK
Type:
Tyrosine-protein kinase
Mol. Mass.:
50707.30
Organism:
Homo sapiens (Human)
Description:
P41240
Residue:
450
Sequence:
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
  
Inhibitor
Name:
BDBM110203
Synonyms:
t-Butyl [2-{5-(2,4-dihydroxybenzoyl)-2-oxopyridin-1(2H)- yl}ethyl]carbamate (33)
Type:
Small organic molecule
Emp. Form.:
C19H22N2O6
Mol. Mass.:
374.3878
SMILES:
CC(C)(C)OC(=O)NCCn1cc(ccc1=O)C(=O)c1ccc(O)cc1O
Structure:
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