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Target3-phosphoinositide-dependent protein kinase 1 (51-359)
LigandBDBM282383
Substrate/Competitorn/a
Meas. Tech.PDK1 kinase assay
IC50<100±n/a nM
Citation Arndt, JChan, TGuckian, KKumaravel, GLee, WLin, EYScott, DSun, LThomas, Jvan Vloten, KWang, DZhang, LErlanson, D Heterocyclic compounds useful as PDK1 inhibitors US Patent US10030016 Publication Date 7/24/2018
More Info.:Get all data from this article,  Assay Method
 
3-phosphoinositide-dependent protein kinase 1 (51-359)
Name:3-phosphoinositide-dependent protein kinase 1 (51-359)
Synonyms:3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide-dependent protein kinase 1 | PDK1 (51-359) | hPDK1
Type:Enzyme Catalytic Domain
Mol. Mass.:35302.26
Organism:Homo sapiens (Human)
Description:n/a
Residue:309
Sequence:
MDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAI
KILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKY
IRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVL
SPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLI
FQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL
HQQTPPKLT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM282383
NameBDBM282383
Synonyms:2-(4-(3-amino-1H-pyrazolo [3,4-b]pyridin-5-yl) benzylamino)-N-(3,4- difluorophenyl)-5- (trifluoromethyl) nicotinamide | US10030016, Example 263
TypeSmall organic molecule
Emp. Form.C26H18F5N7O
Mol. Mass.539.4594
SMILESNc1n[nH]c2ncc(cc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2ccc(F)c(F)c2)C(F)(F)F)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a