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Target3-phosphoinositide-dependent protein kinase 1 (51-359)
LigandBDBM282432
Substrate/Competitorn/a
Meas. Tech.PDK1 kinase assay
IC50<100±n/a nM
Citation Arndt, JChan, TGuckian, KKumaravel, GLee, WLin, EYScott, DSun, LThomas, Jvan Vloten, KWang, DZhang, LErlanson, D Heterocyclic compounds useful as PDK1 inhibitors US Patent US10030016 Publication Date 7/24/2018
More Info.:Get all data from this article,  Assay Method
 
3-phosphoinositide-dependent protein kinase 1 (51-359)
Name:3-phosphoinositide-dependent protein kinase 1 (51-359)
Synonyms:3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide-dependent protein kinase 1 | PDK1 (51-359) | hPDK1
Type:Enzyme Catalytic Domain
Mol. Mass.:35302.26
Organism:Homo sapiens (Human)
Description:n/a
Residue:309
Sequence:
MDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAI
KILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKY
IRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVL
SPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLI
FQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL
HQQTPPKLT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM282432
NameBDBM282432
Synonyms:2-(4-(5-aminopyrazin-2-yl) benzylamino)-5-cyano-N- ((5-fluoropyridin-3-yl)- methyl)nicotinamide | US10030016, Example 312
TypeSmall organic molecule
Emp. Form.C24H19FN8O
Mol. Mass.454.4591
SMILESNc1cnc(cn1)-c1ccc(CNc2ncc(cc2C(=O)NCc2cncc(F)c2)C#N)cc1
Structure
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