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Target3-phosphoinositide-dependent protein kinase 1 (51-359)
LigandBDBM282435
Substrate/Competitorn/a
Meas. Tech.PDK1 kinase assay
IC50<100±n/a nM
Citation Arndt, JChan, TGuckian, KKumaravel, GLee, WLin, EYScott, DSun, LThomas, Jvan Vloten, KWang, DZhang, LErlanson, D Heterocyclic compounds useful as PDK1 inhibitors US Patent US10030016 Publication Date 7/24/2018
More Info.:Get all data from this article,  Assay Method
 
3-phosphoinositide-dependent protein kinase 1 (51-359)
Name:3-phosphoinositide-dependent protein kinase 1 (51-359)
Synonyms:3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide-dependent protein kinase 1 | PDK1 (51-359) | hPDK1
Type:Enzyme Catalytic Domain
Mol. Mass.:35302.26
Organism:Homo sapiens (Human)
Description:n/a
Residue:309
Sequence:
MDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAI
KILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKY
IRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVL
SPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLI
FQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL
HQQTPPKLT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM282435
NameBDBM282435
Synonyms:(S)-3-(4-(4-amino-7H- pyrrolo[2,3-d]pyrimidin- 5-yl)benzylamino)-6- cyano-N-(1-(3,4-difluoro- phenyl)ethyl)pyrazine-2- carboxamide | US10030016, Example 315
TypeSmall organic molecule
Emp. Form.C27H21F2N9O
Mol. Mass.525.5121
SMILESC[C@H](NC(=O)c1nc(cnc1NCc1ccc(cc1)-c1c[nH]c2ncnc(N)c12)C#N)c1ccc(F)c(F)c1 |r|
Structure
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n/a