Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM50265039
Substrate
n/a
Meas. Tech.
sPLA2-V activity assay
pH
8±n/a
Temperature
298.15±n/a K
IC50
5.188e+4± 2.30e+3 nM
Comments
extracted
Citation
 Ahmad, W; Kumolosasi, E; Jantan, I; Bukhari, SN; Jasamai, M Effects of novel diarylpentanoid analogues of curcumin on secretory phospholipase A2 , cyclooxygenases, lipo-oxygenase, and microsomal prostaglandin E synthase-1. Chem Biol Drug Des 83:670-81 (2014) [PubMed]  Article 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM50265039
Synonyms:
(1E,4E)‐1,5‐bis(4‐tert‐butylphenyl)penta‐1,4‐dien‐3‐ one (8) | (1E,4E)-1,5-Bis(4-tert-butylphenyl)penta-1,4-dien-3-one | 1,5-bis(4-tert-butylphenyl)penta-1,4-dien-3-one | CHEMBL498590
Type:
Small organic molecule
Emp. Form.:
C25H30O
Mol. Mass.:
346.5051
SMILES:
CC(C)(C)c1ccc(\C=C\C(=O)\C=C\c2ccc(cc2)C(C)(C)C)cc1
Structure:
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