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TargetPhosphodiesterase 9A
LigandBDBM111913
Substrate/Competitorn/a
Meas. Tech.Scintillation Proximity Assay
pH7.5±n/a
Temperature273.15±n/a K
IC50 6±n/a nM
Citation Giovannini, RDorner-Ciossek, CEickmeier, CFiegen, DFox, TFuchs, KHeine, NRosenbrock, HSchaenzle, G Compounds for the treatment of CNS disorders US Patent US8623901 Publication Date 1/7/2014
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Phosphodiesterase 9A
Name:Phosphodiesterase 9A
Synonyms:High affinity cGMP-specific 3'',5''-cyclic phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A)
Type:Protein
Mol. Mass.:68488.40
Organism:Homo sapiens (human)
Description:O76083
Residue:593
Sequence:
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
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BDBM111913
n/a
NameBDBM111913
Synonyms:US8623901, 241
TypeSmall organic molecule
Emp. Form.C22H20FN5O2
Mol. Mass.405.4249
SMILESFc1ccc(nc1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Structure
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