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Target
Dopa decarboxylase (Aromatic L-amino acid decarboxylase), isoform CRA_a
Ligand
BDBM112634
Substrate
n/a
Meas. Tech.
DDC-MDH-PEPC-Linked assay
pH
8.05±n/a
Temperature
310.15±n/a K
IC50
5.0e+4± 2.3e+3 nM
Comments
extracted
Citation
 Ren, J; Zhang, Y; Jin, H; Yu, J; Zhou, Y; Wu, F; Zhang, W Novel inhibitors of human DOPA decarboxylase extracted from Euonymus glabra Roxb. ACS Chem Biol 9:897-903 (2014) [PubMed]  Article 
Target
Name:
Dopa decarboxylase (Aromatic L-amino acid decarboxylase), isoform CRA_a
Synonyms:
Aromatic-L-amino-acid decarboxylase | DDC | DOPA decarboxylase (DDC)
Type:
Protein
Mol. Mass.:
53899.74
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
480
Sequence:
MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE
  
Inhibitor
Name:
BDBM112634
Synonyms:
Euonyquinone B (7)
Type:
Small organic molecule
Emp. Form.:
C34H34O10
Mol. Mass.:
602.6278
SMILES:
COc1cc(CC=C(c2cc(O)c(OC)cc2O)c2c(OC)cc3OC(CCc3c2O)c2ccc(O)c(OC)c2)ccc1O |w:6.5|
Structure:
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