Reaction Details Report a problem with these data
Target
Vascular endothelial growth factor A
Ligand
BDBM282701
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay (SPA)
pH
7.5±n/a
IC50
18700±n/a nM
Comments
extracted
Citation
 Dixon, DD; Grina, J; Josey, JA; Rizzi, JP; Schlachter, ST; Wallace, EM; Wang, B; Wehn, P; Xu, R; Yang, H Cyclic sulfone and sulfoximine analogs and uses thereof US Patent  US9884843 Publication Date 2/6/2018 
Target
Name:
Vascular endothelial growth factor A
Synonyms:
VEGF | VEGF-A | VEGFA | VEGFA_HUMAN | VPF | Vascular endothelial growth factor (VEGF) | Vascular endothelial growth factor A (VEGF) | Vascular endothelial growth factor A (VEGF2) | Vascular permeability factor
Type:
Protein
Mol. Mass.:
27063.81
Organism:
Homo sapiens (Human)
Description:
P15692
Residue:
232
Sequence:
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
  
Inhibitor
Name:
BDBM282701
Synonyms:
US9884843, Compound 45
Type:
Small organic molecule
Emp. Form.:
C17H9F4NO4S
Mol. Mass.:
399.316
SMILES:
Cc1cc(Oc2ccc3c(C(=O)C(F)(F)S3(=O)=O)c2C(F)F)cc(c1)C#N
Structure:
Search PDB for entries with ligand similarity: