Reaction Details Report a problem with these data
Target
Alpha-galactosidase A
Ligand
BDBM113760
Substrate
n/a
Meas. Tech.
α-Gal A Assay
pH
7±0
IC50
2.18e+3± 3.9e+2 nM
Citation
 Yu, Y; Mena-Barragán, T; Mena-Barragán, K; Johnson, JL; Drury, JE; Lieberman, RL; Nakasone, N; Ninomiya, H; Tsukimura, T; Sakuraba, H; Suzuki, Y; Nanba, E; Mellet, CO; García Fernández, JM; García Fernández, K Molecular Basis of 1-Deoxygalactonojirimycin Arylthiourea Binding to Human a-Galactosidase A: Pharmacological Chaperoning Efficacy on Fabry Disease Mutants. ACS Chem Biol 9:1460-9 (2014) [PubMed]  Article 
Target
Name:
Alpha-galactosidase A
Synonyms:
AGAL_HUMAN | Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | Alpha-galactosidase A | Alpha-glucosidase A (α-Gal A) | GLA | INN=Agalsidase | Melibiase
Type:
Protein
Mol. Mass.:
48760.21
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
429
Sequence:
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTMQMSLKDLL
  
Inhibitor
Name:
BDBM113760
Synonyms:
pF PhIM-DGJ
Type:
Small organic molecule
Emp. Form.:
C13H15FN2O3S
Mol. Mass.:
298.333
SMILES:
O[C@H]1CN2C(CS\C2=N\c2ccc(F)cc2)[C@H](O)[C@@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: