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Target
Disintegrin and metalloproteinase domain-containing protein 10
Ligand
BDBM113839
Substrate
n/a
Meas. Tech.
QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM10.
IC50
9089±n/a nM
Citation
PubChem, PC QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM10. PubChem Bioassay (2014)[AID]
More Info.:
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 10
Synonyms:
ADA10_HUMAN | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) | KUZ | MADM
Type:
Enzyme
Mol. Mass.:
84160.93
Organism:
Homo sapiens (Human)
Description:
O14672
Residue:
748
Sequence:
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR
Inhibitor
Name:
BDBM113839
Synonyms:
(6E)-6-[4-(4-methoxyphenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-(2-methylprop-2-enoxy)-1-cyclohexa-2,4-dienone | (6E)-6-[4-(4-methoxyphenyl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-3-(2-methylprop-2-enoxy)cyclohexa-2,4-dien-1-one | (6E)-6-[4-(4-methoxyphenyl)-5-methyl-3-pyrazolin-3-ylidene]-3-(2-methylallyloxy)cyclohexa-2,4-dien-1-one | 2-[4-(4-Methoxy-phenyl)-5-methyl-1H-pyrazol-3-yl]-5-(2-methyl-allyloxy)-phenol | MLS000551740 | SMR000145665 | cid_9551787
Type:
Small organic molecule
Emp. Form.:
C21H22N2O3
Mol. Mass.:
350.411
SMILES:
COc1ccc(cc1)-c1c(C)[nH]nc1-c1ccc(OCC(C)=C)cc1O