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TargetDisintegrin and metalloproteinase domain-containing protein 10 (ADAM10)
LigandBDBM54807
Substrate/Competitorn/a
Meas. Tech.Counterscreen for exosite inhibitors of ADAM17: Fluorescence resonance energy transfer (FRET)-based biochemical high throughput dose response assay to identify inhibitors of ADAM10
IC50 69509±n/a nM
Citation PubChem, PC Counterscreen for exosite inhibitors of ADAM17: Fluorescence resonance energy transfer (FRET)-based biochemical high throughput dose response assay to identify inhibitors of ADAM10 PubChem Bioassay(2014)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)
Name:Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)
Synonyms:ADAM10
Type:Enzyme
Mol. Mass.:84160.93
Organism:Homo sapiens (Human)
Description:O14672
Residue:748
Sequence:
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
KRRRPPQPIQQPQRQRPRESYQMGHMRR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM54807
NameBDBM54807
Synonyms:4-(2,5-dimethoxyphenyl)-N-[(Z)-3-indolylidenemethyl]-2-(2-methoxyethylimino)-3-thiazolamine | 4-(2,5-dimethoxyphenyl)-N-[(Z)-indol-3-ylidenemethyl]-2-(2-methoxyethylimino)-1,3-thiazol-3-amine | MLS000375345 | SMR000254598 | [4-(2,5-dimethoxyphenyl)-2-(2-methoxyethylimino)-4-thiazolin-3-yl]-[(Z)-indol-3-ylidenemethyl]amine | cid_6508436
TypeSmall organic molecule
Emp. Form.C23H24N4O3S
Mol. Mass.436.527
SMILESCOCCN=c1scc(-c2cc(OC)ccc2OC)n1N=Cc1c[nH]c2ccccc12 |w:20.21,4.3|
Structure
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