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Target
Disintegrin and metalloproteinase domain-containing protein 17
Ligand
BDBM114140
Substrate
n/a
Meas. Tech.
QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM17
IC50
69456±n/a nM
Citation
 PubChem, PC QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM17 PubChem Bioassay (2014)[AID] 
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:
ADA17_HUMAN | ADAM17 | CSVP | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM-17) | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) | TACE | TNF-alpha convertase | TNF-alpha converting enzyme (TACE) | TNF-alpha-converting enzyme (TACE) | Tumor Necrosis Factor Alpha Converting Enzyme | Tumor necrosis factor-α converting enzyme (TACE)
Type:
Enzyme
Mol. Mass.:
93007.89
Organism:
Homo sapiens (Human)
Description:
Residue:
824
Sequence:
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
  
Inhibitor
Name:
BDBM114140
Synonyms:
3-[(3-bromobenzyl)-ethyl-amino]-2-ethyl-N-(3-keto-4H-1,4-benzoxazin-7-yl)imidazo[1,2-a]pyridine-6-carboxamide | 3-[(3-bromophenyl)methyl-ethyl-amino]-2-ethyl-N-(3-oxidanylidene-4H-1,4-benzoxazin-7-yl)imidazo[1,2-a]pyridine-6-carboxamide | 3-[(3-bromophenyl)methyl-ethylamino]-2-ethyl-N-(3-oxo-4H-1,4-benzoxazin-7-yl)-6-imidazo[1,2-a]pyridinecarboxamide | 3-[(3-bromophenyl)methyl-ethylamino]-2-ethyl-N-(3-oxo-4H-1,4-benzoxazin-7-yl)imidazo[1,2-a]pyridine-6-carboxamide | MLS003121316 | SMR001283912 | cid_46942623
Type:
Small organic molecule
Emp. Form.:
C27H26BrN5O3
Mol. Mass.:
548.431
SMILES:
CCN(Cc1cccc(Br)c1)c1c(CC)nc2ccc(cn12)C(=O)Nc1ccc2NC(=O)COc2c1
Structure:
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