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Target
Tyrosyl-DNA phosphodiesterase 2
Ligand
BDBM46593
Substrate
n/a
Meas. Tech.
Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2)
IC50
4202±n/a nM
Citation
 PubChem, PC Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) PubChem Bioassay (2014)[AID] 
Target
Name:
Tyrosyl-DNA phosphodiesterase 2
Synonyms:
EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40916.54
Organism:
Homo sapiens (Human)
Description:
gi_23510348
Residue:
362
Sequence:
MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNSYFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWNIDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQLKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQMNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDIIL
  
Inhibitor
Name:
BDBM46593
Synonyms:
2,6-bis(chloranyl)-N-[2-oxidanyl-1,3-bis(oxidanylidene)inden-2-yl]benzamide | 2,6-dichloro-N-(2-hydroxy-1,3-diketo-indan-2-yl)benzamide | 2,6-dichloro-N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide | 2,6-dichloro-N-(2-hydroxy-1,3-dioxo-2-indenyl)benzamide | 2,6-dichloro-N-(2-hydroxy-1,3-dioxoinden-2-yl)benzamide | MLS000830225 | SMR000458146 | cid_2810445
Type:
Small organic molecule
Emp. Form.:
C16H9Cl2NO4
Mol. Mass.:
350.153
SMILES:
OC1(NC(=O)c2c(Cl)cccc2Cl)C(=O)c2ccccc2C1=O
Structure:
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