Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM42817
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
2085±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM42817
Synonyms:
5-(5-chloranyl-2-methoxy-phenyl)-3H-1,3,4-oxadiazole-2-thione | 5-(5-chloro-2-methoxy-phenyl)-3H-1,3,4-oxadiazole-2-thione | 5-(5-chloro-2-methoxyphenyl)-1,3,4-oxadiazole-2(3H)-thione | 5-(5-chloro-2-methoxyphenyl)-3H-1,3,4-oxadiazole-2-thione | MLS000061371 | SMR000070630 | cid_701063
Type:
Small organic molecule
Emp. Form.:
C9H7ClN2O2S
Mol. Mass.:
242.682
SMILES:
COc1ccc(Cl)cc1-c1nnc(S)o1
Structure:
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