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Target
Major prion protein
Ligand
BDBM114416
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
2070±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM114416
Synonyms:
3-(1,3-benzodioxol-5-yl)-8-[(dimethylamino)methyl]-6-ethyl-7-hydroxy-1-benzopyran-4-one | 3-(1,3-benzodioxol-5-yl)-8-[(dimethylamino)methyl]-6-ethyl-7-hydroxy-chromone | 3-(1,3-benzodioxol-5-yl)-8-[(dimethylamino)methyl]-6-ethyl-7-hydroxychromen-4-one | 3-(1,3-benzodioxol-5-yl)-8-[(dimethylamino)methyl]-6-ethyl-7-oxidanyl-chromen-4-one | MLS001164289 | SMR000539645 | cid_1181832
Type:
Small organic molecule
Emp. Form.:
C21H21NO5
Mol. Mass.:
367.3951
SMILES:
CCc1cc2c(occ(-c3ccc4OCOc4c3)c2=O)c(CN(C)C)c1O
Structure:
Search PDB for entries with ligand similarity: