Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM114447
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1571±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM114447
Synonyms:
2-(5-bromanylnaphthalen-1-yl)carbonylbenzoic acid | 2-(5-bromo-1-naphthoyl)benzoic acid | 2-(5-bromonaphthalene-1-carbonyl)benzoic acid | 2-[(5-bromo-1-naphthalenyl)-oxomethyl]benzoic acid | MLS002639261 | SMR001548707 | cid_232079
Type:
Small organic molecule
Emp. Form.:
C18H11BrO3
Mol. Mass.:
355.182
SMILES:
OC(=O)c1ccccc1C(=O)c1cccc2c(Br)cccc12
Structure:
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