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Target
Group 3 secretory phospholipase A2
Ligand
BDBM50305818
Substrate
n/a
Meas. Tech.
QFRET-based biochemical high throughput dose response assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2)
IC50
31970±n/a nM
Citation
 PubChem, PC QFRET-based biochemical high throughput dose response assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2) PubChem Bioassay (2014)[AID] 
Target
Name:
Group 3 secretory phospholipase A2
Synonyms:
3.1.1.4 | GIII sPLA2 | Group III secretory phopholipase A2 | Group III secretory phospholipase A2 | PA2G3_HUMAN | PLA2G3 | Phosphatidylcholine 2-acylhydrolase 3 | phospholipase A2, group III | sPLA2-III
Type:
PROTEIN
Mol. Mass.:
57196.58
Organism:
Homo sapiens
Description:
ChEMBL_119722
Residue:
509
Sequence:
MGVQAGLFGMLGFLGVALGGSPALRWYRTSCHLTKAVPGNPLGYLSFLAKDAQGLALIHARWDAHRRLQSCSWEDEPELTAAYGALCAHETAWGSFIHTPGPELQRALATLQSQWEACRALEESPAGARKKRAAGQSGVPGGGHQREKRGWTMPGTLWCGVGDSAGNSSELGVFQGPDLCCREHDRCPQNISPLQYNYGIRNYRFHTISHCDCDTRFQQCLQNQHDSISDIVGVAFFNVLEIPCFVLEEQEACVAWYWWGGCRMYGTVPLARLQPRTFYNASWSSRATSPTPSSRSPAPPKPRQKQHLRKGPPHQKGSKRPSKANTTALQDPMVSPRLDVAPTGLQGPQGGLKPQGARWVCRSFRRHLDQCEHQIGPREIEFQLLNSAQEPLFHCNCTRRLARFLRLHSPPEVTNMLWELLGTTCFKLAPPLDCVEGKNCSRDPRAIRVSARHLRRLQQRRHQLQDKGTDERQPWPSEPLRGPMSFYNQCLQLTQAARRPDRQQKSWSQ
  
Inhibitor
Name:
BDBM50305818
Synonyms:
1-(biphenyl-4-ylmethyl)-5-(trifluoromethoxy)indoline-2,3-dione | CHEMBL593506 | cid_45281794
Type:
Small organic molecule
Emp. Form.:
C22H14F3NO3
Mol. Mass.:
397.3467
SMILES:
FC(F)(F)Oc1ccc2N(Cc3ccc(cc3)-c3ccccc3)C(=O)C(=O)c2c1
Structure:
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