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Target
Fibrinogen beta chain [164-491]
Ligand
BDBM114664
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer
IC50
10117±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] PubChem Bioassay (2013)[AID] 
Target
Name:
Fibrinogen beta chain [164-491]
Synonyms:
Chain E, Fragment Double-D From Human Fibrin | FGB | FIBB_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37647.12
Organism:
Homo sapiens (Human)
Description:
gi_28373962
Residue:
328
Sequence:
DNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ
  
Inhibitor
Name:
BDBM114664
Synonyms:
7-[4-(2,3-dimethylphenyl)piperazin-1-yl]sulfonyl-4,6-dimethyl-2,3-dihydro-1,4-benzoxazine | 7-[4-(2,3-dimethylphenyl)piperazino]sulfonyl-4,6-dimethyl-2,3-dihydro-1,4-benzoxazine | 7-[[4-(2,3-dimethylphenyl)-1-piperazinyl]sulfonyl]-4,6-dimethyl-2,3-dihydro-1,4-benzoxazine | MLS001116802 | SMR000627435 | cid_22550831
Type:
Small organic molecule
Emp. Form.:
C22H29N3O3S
Mol. Mass.:
415.549
SMILES:
CN1CCOc2cc(c(C)cc12)S(=O)(=O)N1CCN(CC1)c1cccc(C)c1C
Structure:
Search PDB for entries with ligand similarity: