Reaction Details Report a problem with these data
Target
Fibrinogen beta chain [164-491]
Ligand
BDBM114668
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer
IC50
83300±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] PubChem Bioassay (2013)[AID] 
Target
Name:
Fibrinogen beta chain [164-491]
Synonyms:
Chain E, Fragment Double-D From Human Fibrin | FGB | FIBB_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37647.12
Organism:
Homo sapiens (Human)
Description:
gi_28373962
Residue:
328
Sequence:
DNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ
  
Inhibitor
Name:
BDBM114668
Synonyms:
2-[[5-(1-naphthalenylmethylthio)-1,3,4-thiadiazol-2-yl]thio]-N-[4-(2-thiazolylsulfamoyl)phenyl]acetamide | 2-[[5-(1-naphthylmethylthio)-1,3,4-thiadiazol-2-yl]thio]-N-[4-(thiazol-2-ylsulfamoyl)phenyl]acetamide | 2-[[5-(naphthalen-1-ylmethylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide | 2-[[5-(naphthalen-1-ylmethylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]ethanamide | MLS003128033 | SMR001836093 | cid_24210575
Type:
Small organic molecule
Emp. Form.:
C24H19N5O3S5
Mol. Mass.:
585.764
SMILES:
O=C(CSc1nnc(SCc2cccc3ccccc23)s1)Nc1ccc(cc1)S(=O)(=O)Nc1nccs1
Structure:
Search PDB for entries with ligand similarity: