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Target
Protein artemis
Ligand
BDBM52319
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay
IC50
9580±n/a nM
Citation
 PubChem, PC Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay PubChem Bioassay (2013)[AID] 
Target
Name:
Protein artemis
Synonyms:
ARTEMIS | ASCID | DCLRE1C | DCR1C_HUMAN | SCIDA | SNM1C | protein artemis isoform a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
78427.91
Organism:
Homo sapiens (Human)
Description:
gi_76496497
Residue:
692
Sequence:
MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCRSSQSTEPKYKPLGKLKRARTVHRDSEEEDDYLFDDPLPIPLRHKVPYPETFHPEVFSMTAVSEKQPEKLRQTPGCCRAECMQSSRFTNFVDCEESNSESEEEVGIPASLQGDLGSVLHLQKADGDVPQWEVFFKRNDEITDESLENFPSSTVAGGSQSPKLFSDSDGESTHISSQNSSQSTHITEQGSQGWDSQSDTVLLSSQERNSGDITSLDKADYRPTIKENIPASLMEQNVICPKDTYSDLKSRDKDVTIVPSTGEPTTLSSETHIPEEKSLLNLSTNADSQSSSDFEVPSTPEAELPKREHLQYLYEKLATGESIAVKKRKCSLLDT
  
Inhibitor
Name:
BDBM52319
Synonyms:
4-(1-cyclohex-3-enyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide | 4-(3-cyclohexen-1-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide | 4-cyclohex-3-en-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide | MLS000530517 | SMR000135495 | cid_619328
Type:
Small organic molecule
Emp. Form.:
C18H22N2O2S
Mol. Mass.:
330.444
SMILES:
NS(=O)(=O)c1ccc2NC(C3CC=CC3c2c1)C1CCC=CC1 |c:12,23|
Structure:
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