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Target
Nuclear hormone receptor family member daf-12
Ligand
BDBM114733
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay to identify agonists of the DAF-12 from the parasite H. contortus (hcDAF-12)
EC50
67488±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify agonists of the DAF-12 from the parasite H. contortus (hcDAF-12) PubChem Bioassay (2013)[AID] 
Target
Name:
Nuclear hormone receptor family member daf-12
Synonyms:
DAF12_CAEEL | Protein DAF-12, isoform a | XL285 | daf-12 | daf-20 | mig-7
Type:
Enzyme Catalytic Domain
Mol. Mass.:
84211.49
Organism:
Caenorhabditis elegans
Description:
gi_71987181
Residue:
753
Sequence:
MGTNGGVIAEQSMEIETNENPDKVEEPVVRRKRVTRRRHRRIHSKNNCLTPPNSDDDPQMSTPDDPVIHSPPSIGAAPGMNGYHGSGVKLEESSGACGSPDDGLLDSSEESRRRQKTCRVCGDHATGYNFNVITCESCKAFFRRNALRPKEFKCPYSEDCEINSVSRRFCQKCRLRKCFTVGMKKEWILNEEQLRRRKNSRLNNTGTCNKRSQPGNQQSPQGPNQQPHLSPHHPGVAIYPPQPQRPLTINPMDNQMMHHMQANRPNAMPQLISPPGAQPYPLTSPVGSSASDSPPNRSLTMMHNGEKSPDGYDPNIMAHRAPPPSFNNRPKMDSGQVVLSTEEYKQLLSRIPGAQVPGLMNEEEPINKRAAYNCNGHPMPAETTPPYSAPMSDMSLSRHNSTSSGTEKNHMTHSTVSAIPGNSAQNHFDIASFGMGIVTATGGGDAAEEMYKRMNMFYENCIQSALDSPENQEPKPQEAMIPKEEYMTPTHGFQYQSDPYQVPPAERNINYQLNAAELKALDAVREAFYGMDDPMEQGRQMQSFLKANKTPADIMNIMDVTMRRFVKVAKGVPAFREVSQEGKFSLLKGGMIEMLTVRGVTRYDASTNSFKTPTIKGQNVSVNVDDMFAKLNANAQAQKAKCLEFFGFFDEEIKKNELAVYLVMLAVLFSVRSDPPMNENDVRIVTERHNHFMSLLNRYLESLFGEQARRIFERIPKALGLLNEIARNAGMLFMGTVRSGEAEELPGEFFKIK
  
Inhibitor
Name:
BDBM114733
Synonyms:
4-(2,4-Dimethyl-phenylazo)-3-methyl-5-oxo-4,5-dihydro-pyrazole-1-carbothioic acid amide | 4-(2,4-dimethylphenyl)azo-3-methyl-5-oxo-4H-pyrazole-1-carbothioamide | 4-(2,4-dimethylphenyl)azo-5-keto-3-methyl-2-pyrazoline-1-carbothioamide | 4-[(2,4-dimethylphenyl)diazenyl]-3-methyl-5-oxidanylidene-4H-pyrazole-1-carbothioamide | 4-[(2,4-dimethylphenyl)diazenyl]-3-methyl-5-oxo-4H-pyrazole-1-carbothioamide | MLS000526883 | SMR000117357 | cid_3106473
Type:
Small organic molecule
Emp. Form.:
C13H15N5OS
Mol. Mass.:
289.356
SMILES:
Cc1[nH]n(C(N)=S)c(=O)c1N=Nc1ccc(C)cc1C |w:10.10|
Structure:
Search PDB for entries with ligand similarity: