Reaction Details Report a problem with these data
Target
Oxysterols receptor LXR-beta
Ligand
BDBM115023
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR)
EC50
67475±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR) PubChem Bioassay (2013)[AID] 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM115023
Synonyms:
3-(2-pyridinyl)-6-(2-pyridinylmethylthio)pyridazine | 3-(2-pyridyl)-6-(2-pyridylmethylthio)pyridazine | 3-pyridin-2-yl-6-(pyridin-2-ylmethylsulfanyl)pyridazine | MLS000678515 | SMR000323987 | cid_7162438
Type:
Small organic molecule
Emp. Form.:
C15H12N4S
Mol. Mass.:
280.348
SMILES:
C(Sc1ccc(nn1)-c1ccccn1)c1ccccn1
Structure:
Search PDB for entries with ligand similarity: