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Target
Oxysterols receptor LXR-beta
Ligand
BDBM49991
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR)
EC50
67541±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR) PubChem Bioassay (2013)[AID] 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM49991
Synonyms:
2-chloranyl-5-[2-[(4-methylsulfanylphenyl)methylidene]hydrazinyl]benzoic acid | 2-chloro-5-[(N''E)-N''-[4-(methylthio)benzylidene]hydrazino]benzoic acid | 2-chloro-5-[(N'E)-N'-[4-(methylthio)benzylidene]hydrazino]benzoic acid | 2-chloro-5-[2-[(4-methylsulfanylphenyl)methylidene]hydrazinyl]benzoic acid | 2-chloro-5-[2-[[4-(methylthio)phenyl]methylidene]hydrazinyl]benzoic acid | 2-chloro-5-[N'-[4-(methylthio)benzylidene]hydrazino]benzoic acid | MLS000760472 | SMR000369743 | cid_4122527
Type:
Small organic molecule
Emp. Form.:
C15H13ClN2O2S
Mol. Mass.:
320.794
SMILES:
CSc1ccc(CN=Nc2ccc(Cl)c(c2)C(O)=O)cc1 |w:8.8|
Structure:
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