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Target
Oxysterols receptor LXR-beta
Ligand
BDBM115040
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR)
EC50
67526±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR) PubChem Bioassay (2013)[AID] 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM115040
Synonyms:
(3E)-2-keto-3-vanillylidene-indolizine-1-carbonitrile | (3E)-3-[(3-methoxy-4-oxidanyl-phenyl)methylidene]-2-oxidanylidene-indolizine-1-carbonitrile | (3E)-3-[(4-hydroxy-3-methoxyphenyl)methylidene]-2-oxo-1-indolizinecarbonitrile | (3E)-3-[(4-hydroxy-3-methoxyphenyl)methylidene]-2-oxoindolizine-1-carbonitrile | MLS000776195 | SMR000371201 | cid_6901173
Type:
Small organic molecule
Emp. Form.:
C17H12N2O3
Mol. Mass.:
292.2888
SMILES:
COc1cc(\C=C2\N3C=CC=CC3=C(C#N)C2=O)ccc1O |c:8,10,t:13|
Structure:
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