Reaction Details Report a problem with these data
Target
PC4 and SFRS1-interacting protein
Ligand
BDBM54907
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration
IC50
498.41±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration PubChem Bioassay (2014)[AID] 
Target
Name:
PC4 and SFRS1-interacting protein
Synonyms:
DFS70 | LEDGF | LEDGF/p75 | PSIP1 | PSIP1_HUMAN | PSIP2 | lens epithelium-derived growth factor p75
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60120.68
Organism:
Homo sapiens (Human)
Description:
gi_6708281
Residue:
530
Sequence:
MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN
  
Inhibitor
Name:
BDBM54907
Synonyms:
2-Amino-1-phenethyl-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylic acid (furan-2-ylmethyl)-amide | 2-amino-N-(2-furanylmethyl)-1-(2-phenylethyl)-3-pyrrolo[3,2-b]quinoxalinecarboxamide | 2-amino-N-(2-furfuryl)-1-phenethyl-pyrrolo[3,2-b]quinoxaline-3-carboxamide | 2-amino-N-(furan-2-ylmethyl)-1-(2-phenylethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide | 2-azanyl-N-(furan-2-ylmethyl)-1-(2-phenylethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide | MLS000595296 | SMR000149819 | cid_1912988
Type:
Small organic molecule
Emp. Form.:
C24H21N5O2
Mol. Mass.:
411.4558
SMILES:
Nc1c(C(=O)NCc2ccco2)c2nc3ccccc3nc2n1CCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: