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Target
Urea transporter 1
Ligand
BDBM115188
Substrate
n/a
Meas. Tech.
UT-B Inhibition Assay
IC50
>5.0e+4±n/a nM
Citation
 Esteva-Font, C; Phuan, PW; Anderson, MO; Verkman, AS A small molecule screen identifies selective inhibitors of urea transporter UT-A. Chem Biol 20:1235-44 (2013) [PubMed]  Article 
Target
Name:
Urea transporter 1
Synonyms:
Slc14a1 | UT11 | UT1_RAT | UT3 | Urea transporter B (UT-B)
Type:
Protein
Mol. Mass.:
42037.85
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
384
Sequence:
MEDIPTMVKVDRGESQILSCRGRRCGLKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSDKGDYFWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFCLATLLFLLLTTENPNIYRMPLSKVTYSEENRIFYLQNKKRVVDSPL
  
Inhibitor
Name:
BDBM115188
Synonyms:
N‐(3‐chloro‐4‐methylphenyl)‐8‐methoxy‐2‐ (piperidine‐1‐carbonyl)quinolin‐4‐amine | UT-A1 inhibitor A7
Type:
Small organic molecule
Emp. Form.:
C23H24ClN3O2
Mol. Mass.:
409.909
SMILES:
COc1cccc2c(Nc3ccc(C)c(Cl)c3)cc(nc12)C(=O)N1CCCCC1
Structure:
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