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Target
Urea transporter 1
Ligand
BDBM115198
Substrate
n/a
Meas. Tech.
UT-B Inhibition Assay
IC50
2.8e+3±n/a nM
Citation
 Esteva-Font, C; Phuan, PW; Anderson, MO; Verkman, AS A small molecule screen identifies selective inhibitors of urea transporter UT-A. Chem Biol 20:1235-44 (2013) [PubMed]  Article 
Target
Name:
Urea transporter 1
Synonyms:
Slc14a1 | UT11 | UT1_RAT | UT3 | Urea transporter B (UT-B)
Type:
Protein
Mol. Mass.:
42037.85
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
384
Sequence:
MEDIPTMVKVDRGESQILSCRGRRCGLKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSDKGDYFWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFCLATLLFLLLTTENPNIYRMPLSKVTYSEENRIFYLQNKKRVVDSPL
  
Inhibitor
Name:
BDBM115198
Synonyms:
10‐(4‐bromobenzenesulfonyl)‐N‐[(1Z)‐1λ⁴‐thiophen‐1‐ ylidene]‐5‐thia‐1,8,11,12‐ tetraazatricyclo[7.3.0.0²,⁶]dodeca‐2(6),3,7,9,11‐ pentaen‐7‐amine | UT-A1 inhibitor D3
Type:
Small organic molecule
Emp. Form.:
C17H10BrN5O2S3
Mol. Mass.:
492.393
SMILES:
Brc1ccc(cc1)S(=O)(=O)c1nnn2c3ccsc3c(\[#7]=S3/[#6]=[#6]-[#6]=[#6]3)nc12 |c:24,26|
Structure:
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