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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B
LigandBDBM116309
Substrate/Competitorn/a
Meas. Tech.Scintillation Proximity Assay
pH8±n/a
IC50 4.8±n/a nM
Commentsextracted
Citation Bergmann, JECutshall, NSDemopulos, GAFlorio, VAGaitanaris, GGray, PHohmann, JOnrust, RZeng, H Use of PDE7 inhibitors for the treatment of movement disorders US Patent US8637528 Publication Date 1/28/2014
More Info.:Get all data from this article,  Assay Method
 
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Name:cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Synonyms:Phosphodiesterase 7B | Phosphodiesterase 7B (PDE7B)
Type:Enzyme
Mol. Mass.:51842.76
Organism:Homo sapiens (Human)
Description:Q9NP56
Residue:450
Sequence:
MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYS
GEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIF
LFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAAD
VTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMS
VLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHN
KDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS
PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQ
HRSRGSSGSGPDHDHAGQGTESEEQEGDSP
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  Blast E-value cutoff:
BDBM116309
NameBDBM116309
Synonyms:US8637528, OM69
TypeSmall organic molecule
Emp. Form.C20H25N4O2
Mol. Mass.353.4376
SMILESCOc1cc(N)ccc1-c1cc2c(C(N=[N+]2C)C2CCCCC2)c(=O)[nH]1 |c:15|
Structure
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