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Target
Aurora kinase B
Ligand
BDBM116940
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
2±n/a nM
Citation
 Sutton, AE; Lan, R; Richardson, TE; Perrey, D; Vandeveer, HG; Huck, BR; Karra, SR; Chen, X; Xiao, Y; Liu-Bujalski, L; Goutopoulos, A; Stieber, F; Hodous, BL; Qiu, H; Jones, R; Heasley, BH Amino azaheterocyclic carboxamides US Patent  US8637532 Publication Date 1/28/2014 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM116940
Synonyms:
US8637532, 667
Type:
Small organic molecule
Emp. Form.:
C24H18F3N5O3
Mol. Mass.:
481.4266
SMILES:
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4cccc(OC(F)(F)F)c4)c3)ncnc12
Structure:
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