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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM117019
Substrate
n/a
Meas. Tech.
Radioligand Binding Assays
pH
7.4±0
Temperature
298.15±0 K
IC50
0.26±0.0 nM
Citation
 Teegarden, B; Chapman, D; Choi, J; Feichtinger, K; Han, S; Jayakumar, H; Tran, T; Xu, J; Zou, N Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto US Patent  US8664258 Publication Date 3/4/2014 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM117019
Synonyms:
US8664258, 303 | US9987252, 303
Type:
Small organic molecule
Emp. Form.:
C20H24ClF3N4O2
Mol. Mass.:
444.878
SMILES:
Cn1ncc(Cl)c1-c1cc(NC(=O)C2CCC(CC2)C(F)(F)F)ccc1OCCN |(7.64,.46,;6.87,-.87,;7.35,-2.34,;6.1,-3.24,;4.86,-2.34,;3.53,-3.11,;5.33,-.87,;4,-.1,;2.67,-.87,;1.33,-.1,;,-.87,;-1.33,-.1,;-1.33,1.44,;-2.67,-.87,;-4,-.1,;-5.33,-.87,;-5.33,-2.41,;-4,-3.18,;-2.67,-2.41,;-6.67,-3.18,;-8,-3.95,;-7.44,-1.85,;-5.9,-4.52,;1.33,1.44,;2.67,2.21,;4,1.44,;5.33,2.21,;5.33,3.75,;6.67,4.52,;8,3.75,)|
Structure:
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