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TargetMurE
LigandBDBM119122
Substrate/Competitorn/a
IC50 1.3e+4± 0 nM
Citation Hrast, MSosic, ISink, RGobec, S Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F. Bioorg Chem55:2-15 (2014) [PubMed]  Article
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MurE
Name:MurE
Synonyms:MurE (S. aureus) | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase
Type:Protein
Mol. Mass.:54095.36
Organism:Staphylococcus aureus
Description:Q2FZP6
Residue:493
Sequence:
MDASTLFKKVKVKRVLGSLEQQIDDITTDSRTAREGSIFVASVGYTVDSHKFCQNVADQG
CKLVVVNKEQSLPANVTQVVVPDTLRVASILAHTLYDYPSHQLVTFGVTGTNGKTSIATM
IHLIQRKLQKNSAYLGTNGFQINETKTKGANTTPETVSLTKKIKEAVDAGAESMTLEVSS
HGLVLGRLRGVEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDLSKEKYVVLNN
DDSFSEYLRTVTPYEVFSYGIDEEAQFMAKNIQESLQGVSFDFVTPFGTYPVKSPYVGKF
NISNIMAAMIAVWSKGTSLETIIKAVENLEPVEGRLEVLDPSLPIDLIIDYAHTADGMNK
LIDAVQPFVKQKLIFLVGMAGERDLTKTPEMGRVACRADYVIFTPDNPANDDPKMLTAEL
AKGATHQNYIEFDDRAEGIKHAIDIAEPGDTVVLASKGREPYQIMPGHIKVPHRDDLIGL
EAAYKKFGGGPVD
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  Blast E-value cutoff:
BDBM119122
n/a
NameBDBM119122
Synonyms:MurA/B/C/D/E inhibitor (compound 67)
TypeSmall organic molecule
Emp. Form.C22H13F3O3
Mol. Mass.382.332
SMILESFC(F)(F)c1ccc(cc1)C1C(=O)OC(=Cc2cccc3ccccc23)C1=O |w:15.16|
Structure
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