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TargetN-lysine methyltransferase SMYD2
LigandBDBM283178
Substrate/Competitorn/a
Meas. Tech.Scintillation Proximity Assay (SPA) for Detection of SMYD2 Enzymatic Inhibition
pH9±n/a
IC50 1070±n/a nM
Commentsextracted
Citation Mowat, JSStellfeld, TStresemann, CHillig, RKöhr, SStöckigt, DWeiske, JBrumby, TBarak, NChrist, CTer Laak, ABadock, VCrampton, RHStefanuti, I Aryl-cyanoguanidine compounds US Patent US10023539 Publication Date 7/17/2018
More Info.:Get all data from this article,  Assay Method
 
N-lysine methyltransferase SMYD2
Name:N-lysine methyltransferase SMYD2
Synonyms:HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SMYD2
Type:Enzyme
Mol. Mass.:49689.57
Organism:Homo sapiens (Human)
Description:Q9NRG4
Residue:433
Sequence:
MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKE
GLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHP
ERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVN
CNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSY
IDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARN
VIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGAL
QYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDH
PYISEIKQEIESH
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  Blast E-value cutoff:
BDBM283178
NameBDBM283178
Synonyms:Rac-N-[1-{N′-cyano-N-[3-(2,2,2-trifluoroethyl)phenyl]carbamimidoyl}-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl]-N-ethyl-2-hydroxyacetamide | US10023539, Example 21
TypeSmall organic molecule
Emp. Form.C23H21Cl2F3N6O2
Mol. Mass.541.353
SMILESCCN(C1CN(N=C1c1ccc(Cl)c(Cl)c1)C(\Nc1cccc(CC(F)(F)F)c1)=N/C#N)C(=O)CO |w:3.2,c:6|
Structure
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