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TargetN-lysine methyltransferase SMYD2
LigandBDBM283207
Substrate/Competitorn/a
Meas. Tech.Scintillation Proximity Assay (SPA) for Detection of SMYD2 Enzymatic Inhibition
pH9±n/a
IC50 231±n/a nM
Commentsextracted
Citation Mowat, JSStellfeld, TStresemann, CHillig, RKöhr, SStöckigt, DWeiske, JBrumby, TBarak, NChrist, CTer Laak, ABadock, VCrampton, RHStefanuti, I Aryl-cyanoguanidine compounds US Patent US10023539 Publication Date 7/17/2018
More Info.:Get all data from this article,  Assay Method
 
N-lysine methyltransferase SMYD2
Name:N-lysine methyltransferase SMYD2
Synonyms:HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SMYD2
Type:Enzyme
Mol. Mass.:49689.57
Organism:Homo sapiens (Human)
Description:Q9NRG4
Residue:433
Sequence:
MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKE
GLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHP
ERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVN
CNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSY
IDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARN
VIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGAL
QYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDH
PYISEIKQEIESH
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BDBM283207
NameBDBM283207
Synonyms:N-[3-(4-chloro-3-methylphenyl)-1-{N′-cyano-N-[3-(difluoromethoxy)phenyl]carbamimidoyl}-4,5-dihydro-1H-pyrazol-4-yl]-N-ethyl-N2-methyl-D-alaninamide | US10023539, Example 37
TypeSmall organic molecule
Emp. Form.C25H28ClF2N7O2
Mol. Mass.531.985
SMILESCCN(C1CN(N=C1c1ccc(Cl)c(C)c1)C(\Nc1cccc(OC(F)F)c1)=N/C#N)C(=O)[C@@H](C)NC |r,w:3.2,c:6|
Structure
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