Target
Prephenate dehydrogenase
Ligand
BDBM119878
Substrate
n/a
Meas. Tech.
Enzyme Assays
Ki
155±14 nM
Citation
 Bryk, RArango, NMaksymiuk, CBalakrishnan, AWu, YTWong, CHMasquelin, THipskind, PLima, CDNathan, C Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry 52:9375-84 (2013) [PubMed]  Article 
Target
Name:
Prephenate dehydrogenase
Synonyms:
Prephenate dehydrogenase TyrA (PDH) | TYRA_MYCTU | tyrA
Type:
Protein
Mol. Mass.:
33096.86
Organism:
Mycobacterium tuberculosis H37Rv
Description:
O69721
Residue:
323
Sequence:
MTRTVAAPPVCVLGLGLIGGSIMRAAAAAGREVFGYNRSVEGAHGARSDGFDAITDLNQTLTRAAATEALIVLAVPMPALPGMLAHIRKSAPGCPLTDVTSVKCAVLDEVTAAGLQARYVGGHPMTGTAHSGWTAGHGGLFNRAPWVVSVDDHVDPTVWSMVMTLALDCGAMVVPAKSDEHDAAAAAVSHLPHLLAEALAVTAAEVPLAFALAAGSFRDATRVAATAPDLVRAMCEANTGQLAPAADRIIDLLSRARDSLQSHGSIADLADAGHAARTRYDSFPRSDIVTVVIGADKWREQLAAAGRAGGVITSALPSLDSPQ
  
Inhibitor
Name:
BDBM119878
Synonyms:
SL827 | US9073941, 500
Type:
Small organic molecule
Emp. Form.:
C15H17BrN4O4S
Mol. Mass.:
429.289
SMILES:
COc1ccc(NC(=O)CN(C)S(=O)(=O)c2cc(Br)cnc2N)cc1
Structure:
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