Reaction Details Report a problem with these data
Target
Cathepsin H
Ligand
BDBM120839
Substrate
n/a
Meas. Tech.
Enzymatic activity assay
pH
6±n/a
Temperature
310.15±n/a K
Ki
12.7±1.265 nM
Comments
extracted
Citation
 Raghav, N; Garg, S N-formylpyrazolines and N-benzoylpyrazolines as novel inhibitors of mammalian cathepsin B and cathepsin H. Bioorg Chem 57:43-50 (2014) [PubMed]  Article 
Target
Name:
Cathepsin H
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
37394.24
Organism:
Capra hircus (Goat)
Description:
A0A060INS8
Residue:
335
Sequence:
MWAVLPLLCAGAWLLGAPACGAAELAVNSLEKFHFQSWMVQHQKKYSSEEYHHRLQVFASNLREINAHNARNHTFKMGLNQFSDMSFAELKRKYLWSEPQNCSATKSNYLRGTGPYPPSMDWREKGNFVTPVKNQGSCGSCWTFSTTGALESAVAIATGKLPFLAEQQLVDCAQNFNNHGCQGGLPSQAFEYIRYNKGIMGEDTYPYRGQDGDCKYQPSKAIAFVKDVANITLNDEEAMVEAVALYNPVSFAFEVTADFMMYRKGIYSSTSCHKTPDKVNHAVLAVGYGEEKGIPYWIVKNSWGPHWGMKGYFLIERGKNMCGLAACASFPIPLV
  
Inhibitor
Name:
BDBM120839
Synonyms:
N-benzoyl-5-(-4'-nitrophenyl)-3-phenylpyrazoline (2j)
Type:
Small organic molecule
Emp. Form.:
C22H17N3O3
Mol. Mass.:
371.3887
SMILES:
[O-][N+](=O)c1ccc(cc1)C1CC(=NN1C(=O)c1ccccc1)c1ccccc1 |c:12|
Structure:
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