Reaction Details Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM283706
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay on Rat TAAR1
pH
7.4±n/a
Ki
15±n/a nM
Comments
extracted
Citation
 Cecere, G; Galley, G; Norcross, R; Pflieger, P; Rauber, E Substituted azetidine derivatives US Patent  US10023559 Publication Date 7/17/2018 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_RAT | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Enzyme
Mol. Mass.:
38034.73
Organism:
Rattus norvegicus (Rat)
Description:
Q923Y9
Residue:
332
Sequence:
MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM283706
Synonyms:
N-[4-(azetidin-3-yloxy)phenyl]-4-bromo-3-cyclopropyl-1H-pyrazole-5-carboxamide | US10023559, Example 31
Type:
Small organic molecule
Emp. Form.:
C16H17BrN4O2
Mol. Mass.:
377.236
SMILES:
Brc1c(n[nH]c1C(=O)Nc1ccc(OC2CNC2)cc1)C1CC1
Structure:
Search PDB for entries with ligand similarity: