Reaction Details Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM283745
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay on Rat TAAR1
pH
7.4±n/a
Ki
9.90±n/a nM
Comments
extracted
Citation
 Cecere, G; Galley, G; Norcross, R; Pflieger, P; Rauber, E Substituted azetidine derivatives US Patent  US10023559 Publication Date 7/17/2018 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_RAT | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Enzyme
Mol. Mass.:
38034.73
Organism:
Rattus norvegicus (Rat)
Description:
Q923Y9
Residue:
332
Sequence:
MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM283745
Synonyms:
N-[4-[(3-fluoroazetidin-3-yl)methyl]phenyl]-5-(trifluoromethyl)pyrazine-2-carboxamide | US10023559, Example 70
Type:
Small organic molecule
Emp. Form.:
C16H14F4N4O
Mol. Mass.:
354.3022
SMILES:
FC(F)(F)c1cnc(cn1)C(=O)Nc1ccc(CC2(F)CNC2)cc1
Structure:
Search PDB for entries with ligand similarity: