Reaction Details Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM283757
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay on Rat TAAR1
pH
7.4±n/a
Ki
5.50±n/a nM
Comments
extracted
Citation
 Cecere, G; Galley, G; Norcross, R; Pflieger, P; Rauber, E Substituted azetidine derivatives US Patent  US10023559 Publication Date 7/17/2018 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_RAT | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Enzyme
Mol. Mass.:
38034.73
Organism:
Rattus norvegicus (Rat)
Description:
Q923Y9
Residue:
332
Sequence:
MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM283757
Synonyms:
N-(4-(azetidin-3-ylidenemethyl)-3,5-difluorophenyl)-6-methyl-2-(trifluoromethyl)pyrimidine-4-carboxamide | US10023559, Example 82
Type:
Small organic molecule
Emp. Form.:
C17H13F5N4O
Mol. Mass.:
384.3033
SMILES:
[#6]-c1cc(nc(n1)C(F)(F)F)-[#6](=O)-[#7]-c1cc(F)c(\[#6]=[#6]-2/[#6]-[#7]-[#6]-2)c(F)c1
Structure:
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