Reaction Details Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM283763
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay on Rat TAAR1
pH
7.4±n/a
Ki
5.00±n/a nM
Comments
extracted
Citation
 Cecere, G; Galley, G; Norcross, R; Pflieger, P; Rauber, E Substituted azetidine derivatives US Patent  US10023559 Publication Date 7/17/2018 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_RAT | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Enzyme
Mol. Mass.:
38034.73
Organism:
Rattus norvegicus (Rat)
Description:
Q923Y9
Residue:
332
Sequence:
MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM283763
Synonyms:
N-(4-(azetidin-3-ylidenemethyl)-3-fluorophenyl)-3-ethyl-4-methyl-1H-pyrazole-5-carboxamide | US10023559, Example 88
Type:
Small organic molecule
Emp. Form.:
C17H19FN4O
Mol. Mass.:
314.3574
SMILES:
CCc1n[nH]c(C(=O)Nc2ccc(C=C3CNC3)c(F)c2)c1C |(-5.6,-4.26,;-6.22,-2.84,;-5.3,-1.61,;-5.77,-.14,;-4.53,.76,;-3.28,-.14,;-1.79,.26,;-1.4,1.74,;-.71,-.83,;.78,-.43,;1.87,-1.52,;3.36,-1.12,;3.76,.36,;5.24,.76,;6.33,-.33,;6.33,-1.87,;7.87,-1.87,;7.87,-.33,;2.67,1.45,;3.07,2.94,;1.18,1.05,;-3.73,-1.64,;-2.83,-2.89,)|
Structure:
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