Reaction Details Report a problem with these data
Target
Prokineticin receptor 2
Ligand
BDBM121070
Substrate
n/a
Meas. Tech.
Calcium Mobilization Assay
Temperature
310.15±n/a K
Ki
1.7±n/a nM
Comments
extracted
Citation
 Zhou, Q; Li, J; Huang, Q Prokineticin receptor antagonists and uses thereof US Patent  US8722896 Publication Date 5/13/2014 
Target
Name:
Prokineticin receptor 2
Synonyms:
Prokineticin receptor 2 (PRK2)
Type:
Enzyme
Mol. Mass.:
44473.96
Organism:
Cricetulus griseus (Chinese hamster)
Description:
G3H407
Residue:
391
Sequence:
MPPAGINMASQNKNTSFAPDLNPSQDHISSLPFNFSYSDYDLPLDGDEDMTKTQTFFAAKIVIGVALAGIMLVCGIGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFTTETILDIVKNQEKIFCGQIWPVDQQLYYKSYFLFVFGLEFVGPVVAMTLCYARISQELWFKAVPGFQTEQIRKRLRCRRKTVLLLMGILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTICFVTVKNNTMKYFKKMLLLHWQPSRYGSKSSADLDLKTSGVPATEEVDCIRLK
  
Inhibitor
Name:
BDBM121070
Synonyms:
US8722896, (-)-(3R)-1-(2-Methoxybenzyl)- N-(9-fluoro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Type:
Small organic molecule
Emp. Form.:
C27H35FN2O4
Mol. Mass.:
470.5762
SMILES:
COc1ccccc1CN1CC[C@H](C1)C(=O)N(CC(C)C)Cc1cc(F)c2OCCCOc2c1 |r|
Structure:
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